SELECT 
  DISTINCT product_id 
FROM 
  cscart_product_features_values 
WHERE 
  product_id IN (
    21181, 21182, 21183, 21184, 21185, 21186, 
    21187, 21188, 21189, 21190, 21191, 
    21192, 21193, 21194, 21195, 21196
  ) 
  AND feature_id IN (116) 
  AND (
    UPPER(value) IN ('Y', 'YES', 'TRUE', '1') 
    OR value IN (
      '해외구매대행', '수입품', 
      'Imported'
    ) 
    OR value_int > 0
  )

Query time 0.00083

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "table_name": "cscart_product_features_values",
      "access_type": "range",
      "possible_keys": [
        "PRIMARY",
        "fl",
        "product_id",
        "fpl",
        "idx_product_feature_variant_id"
      ],
      "key": "fpl",
      "key_length": "6",
      "used_key_parts": ["feature_id", "product_id"],
      "rows": 16,
      "filtered": 100,
      "index_condition": "cscart_product_features_values.feature_id = 116 and cscart_product_features_values.product_id in (21181,21182,21183,21184,21185,21186,21187,21188,21189,21190,21191,21192,21193,21194,21195,21196)",
      "attached_condition": "ucase(cscart_product_features_values.`value`) in ('Y','YES','TRUE','1') or cscart_product_features_values.`value` in ('해외구매대행','수입품','Imported') or cscart_product_features_values.value_int > 0"
    }
  }
}